Selected Publications

 2010

Kolodziejek, I., and Van der Hoorn, R. A. L. (2010) Mining the active plant proteome in plant science and biotechnology. Curr. Opin. Biotechn. 21, 225-233. pubmed

Gu, C., Kolodziejek, I., Misas-Villamil, J., Sindo, T., Colby, T., Verdoes, M., Richau, K., Schmidt, J., Overkleeft, H., and Van der Hoorn, R. A. L. (2010) Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defence-induced proteasome activities. Plant J. 62, 160-170. pubmed

Toth, R., and Van der Hoorn, R. A. L. (2010) Emerging principles in plant chemical genetics. Trends in Plant Sci. 15, 81-88. pubmed

2009

Kaschani*, F., Gu*, C., Niessen, S., Hoover, H., Cravatt, B. F., and Van der Hoorn, R. A. L. (2009) Diversity of Serine hydrolase activities of non-challenged and Botrytis-infected Arabidopsis thaliana. Mol. Cell. Proteomics 8, 1082-1093 pubmed

Song, J., Win, J., Tian, M., Schornack, S., Kaschani, F., Muhammad, I., Van der Hoorn, R. A. L., and Kamoun, S. (2009) Apoplastic effectors secreted by two unrelated eukaryotic plant pathogens target the tomato defense protease Rcr3. Proc. Natl. Acad. Sci. USA 106, 1654-1659. pubmed

Hogenhout, S. A., Van der Hoorn, R. A. L., Terauchi, R., and Kamoun, S. (2009) Emerging concepts in effector biology of plant-associated organisms. Mol. Plant-Microbe Interact. 22, 115-122. pubmed

Kaschani, F., Verhelst, S. H. L., Van Swieten, P. F., Verdoes, M., Wong, C. -S., Wang, Z., Kaiser, M., Overkleeft, H. S., Bogyo, M., and Van der Hoorn, R. A. L. (2009) Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click-chemistry'. Plant J. 57, 373-385. pubmed

2008

Van der Hoorn, R. A. L., and Kamoun, S. (2008) From guard to decoy: a new model for perception of plant pathogen effectors. Plant Cell 20, 2009-2017. pubmed

Wang*, Z., Gu*, C., Colby, T., Shindo, T., Balamurugan, R., Waldmann, H., Kaiser, M., and Van der Hoorn, R. A. L. (2008) Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nat. Chem. Biol. 4, 557-563. pubmed Highlighted by Carrico. I. (2008) Unexpected N-terminal processing: a cysteine protease that cuts and pastes. Nat. Chem. Biol. 4, 525-526. pubmed pressrelease (German)

Misas-Villamil, J. C., and Van der Hoorn, R. A. L. (2008) Enzyme-inhibitor interactions at the plant-pathogen interface. Curr. Opin. Plant Biol. 11, 380-388 pubmed

Shabab*, M., Shindo*, T., Gu, C., Kaschani, F., Pansuriya, T., Chintha, R., Harzen A., Colby, T., Kamoun, S., and Van der Hoorn, R. A. L. (2008) Fungal effector protein AVR2 targets diversifying defence-related Cys proteases of tomato. Plant Cell 20, 1169-1183. pubmed

Van der Hoorn, R. A. L. (2008) Plant proteases: from phenotypes to molecular mechanisms. Ann. Rev. Plant Biol. 59, 191-223. pubmed

Shindo, T., and Van der Hoorn, R. A. L. (2008) Papain-like cysteine proteases: key players at molecular battlefields employed by both plants and their invaders. Mol. Plant Pathol. 9, 119-125. MPP

2007

Gilroy, E., Hein, I., Van der Hoorn, R. A. L., Boevink, P., Venter, E., McLellan, H., Kaffarnik, F., Hrubikova, K., Shaw, J., Holeva, M., Lopez, E., Hidalgo, O., Pritchard, L., Loake, G., Lacomme, C., and Birch, P. (2007) Involvement of cathepsin B in the plant disease resistance hypersensitive response. Plant J. 52, 1-13. pubmed

Kaschani, F., and Van der Hoorn, R. A. L. (2007) Anwendung von activity-based proteomics zur Analyse von Pflanzen-Pathogen Interaktionen. Max Planck Society Yearbook 2007, 625-629. link

Kaschani, F., and Van der Hoorn, R. A. L. (2007) Small molecule approaches in plants. Curr. Opin. Chem. Biol. 11, 88-98. pubmed

Tian, M., Win, J., Song, J., Van der Hoorn, R. A. L., Van der Knaap, E., and Kamoun, S. (2007) A Phytophthora infestans cystatin-like protein interacts with and inhibits a tomato papain-like apoplastic protease. Plant Physiol. 143, 364-277. pubmed

2005

Rooney*, H., Van ’t Klooster*, J., Van der Hoorn, R. A. L., Joosten, M. H. A. J., Jones, J. D. G., and De Wit, P. J. G. M. (2005) Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance. Science 308, 1783-1789. pubmed
Recommended in faculty 1000.

Van der Hoorn*, R. A. L., Wulff*, B., Rivas*, S., Durrant, M. C., Van der Ploeg, A., De Wit, P. J. G. M., and Jones, J. D. G.
(2005) Structure-function analysis of Cf-9, a receptor-like protein with extracytoplasmic leucine-rich repeats. Plant Cell 17, 1000-1015. pubmed

2004

Van der Hoorn, R. A. L. and Jones, J. D. G. (2004) The plant proteolytic machinery and its role in defence. Curr. Opin. Plant Biol. 7, 400-407. pubmed

Van der Hoorn, R. A. L., Leeuwenburgh, M. A, Bogyo, M., Joosten, M. H. A. J., and Peck, S. C. (2004) Activity profiling of papain-like cysteine proteases in plants. Plant Physiol. 135, 1170-1178. pubmed
Technical advance, recommended by faculty 1000.

2003

Van der Hoorn, R. A. L., Rivas, S., Wulff, B. B. H., Jones, J. D. G., and Joosten, M. H. A. J. (2003). Rapid migration in gel filtration of the Cf-4 and Cf-9 resistance proteins is an intrinsic property of Cf proteins and not because of their association with high-molecular-weight proteins. Plant J. 35, 305-315. pubmed

2002

Van der Hoorn, R. A. L., De Wit, P. J. G. M., and Joosten, M. H. A. J. (2002) Balancing selection favors guarding resistance proteins. Trends Plant Sci. 6, 67-71. pubmed

2001

Van der Hoorn, R. A. L., Roth, R., and De Wit, P. J. G. M. (2001) Identification of distinct specificity determinants in resistance protein Cf-4 allows construction of a Cf-9 mutant that confers recognition of avirulence protein AVR4. Plant Cell 13, 273-285. pubmed

Van der Hoorn, R. A. L., Van der Ploeg, A., De Wit, P. J. G. M., and Joosten, M. H. A. J.
(2001) The C-terminal dilysine motif for targeting to the endoplasmic reticulum is not required for Cf-9 function. Mol. Plant-Microbe Interact. 14, 412-415. pubmed

Van der Hoorn*, R. A. L., Kruijt*.
M., Roth, R., Brandwagt, B. F., Joosten, M. H. A. J., and De Wit, P. J. G. M. (2001) Intragenic recombination generated two distinct Cf genes that mediate AVR9 recognition in the natural population of Lycopersicon pimpinellifolium. Proc. Natl. Acad. Sci. USA 98, 10493-10498. pubmed

2000

Van der Hoorn, R.A.L., Laurent, F., Roth, R., and De Wit, P.J.G.M. (2000) Agroinfiltration is a versatile tool that facilitates comparative analysis of Avr9/Cf-9-induced and Avr4/Cf-4-induced necrosis. Mol. Plant-Microbe Interact. 13,439-446. pubmed

Luderer, R., Rivas, S., Nürnberger, T., Mattei, B., Van den Hooven, H. W., Van der Hoorn, R. A. L., Romeis, T., Wehrfritz, J. M., Blume, B., Nennstiel, D., Zuidema, D., Vervoort, J., De Lorenzo, G., Jones, J. D. G., De Wit, P. J. G. M., and Joosten, M. H. A. J.
(2000) No evidence for binding between resistance gene product Cf-9 of tomato and avirulence gene product AVR9 of Cladosporium fulvum. Mol. Plant-Microbe Interact. 14, 867-876. pubmed

Stam, M., De Bruin, R., Van Blokland, R., Van der Hoorn, R. A. L., Mol, J. N. M., and Kooter, J. M.
(2000) Distinct features of post-transcriptional gene silencing by antisense transgenes in single copy and inverted T-DNA repeat loci. Plant J. 21, 27-42. pubmed

1997

Stam, M., De Bruin, R., Kenter, S., Van der Hoorn, R. A. L., Van Blokland, R., Mol, J. N. M., and Kooter, J. M. (1997) Post-transcriptional silencing of chalcone synthase in Petunia by inverted transgene repeats. Plant J. 12, 63-82.

*, equal contibutions