Publications
2019
117. Buscaill, P., Chandrasekar, B., Sanguankiattichai, N., Kourelis, J., Kaschani, F., Thomas, E. L., Morimoto, K., Kaiser, M., Preston, G. M., Ichinose, Y., and Van der Hoorn, R. A. L. (2019) Glycosidase and glycan polymophism control hydrolytic release of immunogenic flagellin peptides. Science 364, 145. link
116. Fernandez-Fernandez, A. D., Van der Hoorn, R. A. L., Gevaert, K., Van Beusegem, F., and Stael, S. (2019) Caught green-handed: methods for in vivo detection and visualization of protease activity. J. Exp. Bot. in press. pubmed
115. Vinegra de la Torre, N., Kaschani, F., Kaiser, M., Van der Hoorn, R. A. L., Soppe, W. J. J., and Misas-Villamil, J. C. (2019) Dynamic hydrolase labelling as a marker for seed quality in Arabidopsis seeds. Biochem. J. 476, 843-857. pubmed
114. Pogorelko, P., Juvale, P., Rutter, W., Hütten, M., Maier, T., Hewezi, T., Paulus, J. K., Van der Hoorn, R. A. L., Grundler, F., Siddique, S., Lionetti, V., Zabotina, O., Baum, T. (2019) Retargeting of a defence protease by a nematode effector. Plant J. in press. pubmed
113. Jutras, P. V. , Grosse-Holz, F., Kaschani, F., Kaiser, M., Michaud, D., and Van der Hoorn, R. A. L. (2019) Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilising inhibuitor SlCYS8 in Nicotiana benthamiana. Plant Biotechn. J. in press. pubmed
112. Poret, M., Chandrasekar, B., Dechaumet S., Bouchereau, A., Kim, T. H., Lee, B. R., Macquart F., Hara-Nishimura I, Van der Hoorn, R. A. L., Avice, J. C. (2019) A genotypic comparison reveals that the improvement in nitrogen remobilisation efficiency in oilseed rape leaves is related to specific patterns of senescence-associated protease activities and phytohormones. Front Plant Sci 10,46.
111. Paulus, J. K. and Van der Hoorn, R. A. L. (2019) Do proteolytic cascades exist in plants? J. Exp. Bot. in press pubmed
110. Santos, R. B., Pires, A. S., Van der Hoorn, R. A. L., Schiermeyer, A., and Abranches, R. (2018) Generation of transgenic cell suspension cultures of the model legume Medicago truncatula: a rapid method for Agrobacterium-mediated gene transfer. Plant Cell & Organ Culture (PCTOC) 13, e1800050. pubmed
109. Ormancey, M., Thuleau P., Van der Hoorn, R. A. L., Grat, S., Testard, A., Kamal, K. Y., Boudsocq, M., Cotelle, V., and Mazars, C. (2018) Shingolipid-induced cell death in Arabidopsis is negatively regulated by the papain-like cysteine protease RD21. Plant Sci. 280, 12-17. pubmed
2018
108. Bravo Cadena, M., Preston, G. M., Van der Hoorn, R. A. L., Townley, H. E., Thompson, I. P. (2018) Species-specific antimicrobial activity of essential oils and enhancement by encapsulation in mesoporous silica nanoparticles. Ind. Crops & Products 122, 582-590.
107. Van der Hoorn, R. A. L. and Rivas, S. (2018) Unravelling the role of plant proteases. New Phytol. 218, 879-881. pubmed
106. Clark, K., Franco, J., Schwizer, S., Pang, Z., Hawara, E., Liebrand, T., Pagliaccia, D., Zeng, L., Gurung, F., Wang, P., Shi, J., Wang, Y., Ancona, V., Van der Hoorn, R. A. L., Wang, N., Coaker, G., and Ma, W. (2018) An effector from the Huanglongbing-associated pathogen targets citrus proteases. Nat. Comm. 9, 1718 pubmed
105. Planas, M., Bernardo-Faura, M., Paulus, J. K., Kaschani, F., Kaiser, M., Valls, M., Van der Hoorn, R. A. L., and Coll, N. (2018) Protease activities triggered by Ralstonia solanacearum infection in susceptible and tolerant tomato lines. Mol. Cell. Proteomics 17, 1112-1125 pubmed
104. Santos, R. B., Chandrasekar, B., Mandal, M. K., Kaschani, F., Kaiser, M., Both, L., Van der Hoorn, R. A. L., Schiermeyer, A., Abranches R. (2018) Low protease content in Medicago truncatula cell cultures facilitates recombinant protein production. Biotechn. J. 13, e1800050 pubmed
103. Husaini, A. M., Morimoto, K., Chandrasekar, B., Kelly, S., Kaschani, F., Palmero, D., Jiang, J., Kaiser, M., Ahrazem, O., Overkleeft, H. S., and Van der Hoorn, R. A. L. (2018) Multiplex fluorescent activity profiling of α-glycosidases in plants. Plant Physiol. 177, 24-37. pubmed
102. Grosse-Holz, F., Madeira, L., Zahid, M. A., Songer, M., Kourelis, J., Fesenko, M., Ninck, S., Kaschani, F., Kaiser, M. and Van der Hoorn, R. A. L. (2018) Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in N. benthamiana. Plant Biotechn. J. 16, 1797-1810. pubmed
101. Thomas, E. L., and Van der Hoorn, R. A. L. (2018) Ten prominent host protease in plant-pathogen interactions. Int. J. Mol. Sci. 19, 639. pubmed
100!. Kourelis, J., and Van der Hoorn, R. A. L. (2018) Defended to the nines: 25 years of resistance gene cloning identifies nine mechanisms of R protein function. Plant Cell 30, 285-299. pubmed
99. Paulus, J. K. and Van der Hoorn, R. A. L. (2018) Tricked or Trapped - two decoy mechanisms in host-pathogen interactions' PLoS Pathog. 14, e1006761. pubmed
2017
98. Zhang, H., Gannon, L., Hassall, K., Deery, M., Gibbs, D., Holdsworth, M., Van der Hoorn, R. A. L., Lilley, K., and Theodoulou, F. (2017) N-terminomics reveal control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway. New Phytol. 218, 1106-1126. pubmed
97. Grosse-Holz, F., Kelly, S., Blaskowski, S., Kaschani, F., Kaiser, M., and Van der Hoorn, R. A. L. (2017) The transcriptome, extracellular proteome and active secretome of agroinfiltrated N. benthamiana uncover a large, diverse protease repertoire. Plant Biotechn. J. 16, 1068-1084. pubmed
96. Poret, M., Chandrasekar, B., Van der Hoorn, R. A. L., Coquet, L., Jouenne, T., and Avice, J. -C. (2017) Proteomic investigations of proteases involved in cotyledon senescence: a model to explore the genotypic variability of proteolysis machinery associated with nitrogen remobilisation efficiency during leaf senescence of oilseed rape. Proteomes 5, 29. pubmed
95. Teper-Bamnolker, P., Buskila, Y., Belausov, E., Wolf, D., Doron-Faigenboim, A., Ben-Dor, S., Van der Hoorn, R. A. L., Lers, A., Eshel, D. (2017) Vacuolar processing enzyme (VPE) activates programmed cell death in the apical meristem inducing loss of apical dominance. Plant Cell & Environ. 40, 2381-2392. pubmed
+++ Lu, H., Chandrasekar, B., Oeljeklaus, J., Misas-Villamil, J. C., Wang, Z., Shindo, T., Bogyo, M., Kaiser, M., and Van der Hoorn, R. A. L. Correction in Plant Physiol. 174, 465-466 on Ref.72 link
+++ Van der Hoorn, R. A. L., Rivas, S., Wulff, B. B. H., Jones, J. D. G., and Joosten, M. H. A. J. Correction in Plant J. 90, 1212 on Ref.11 link
94. Schaller, A., Stintzi, A., Rivas, S., Serano, I., Sueldo, D. J., Van der Hoorn, R. A. L., Ramirez, V., Vera, P. (2017) From structure to function - a family portrait of plant subtilases. New Phytol. 218, 901-915. pubmed
93. Paulus, J. K., Kourelis, J., and Van der Hoorn, R. A. L. (2017) Bodyguards: pathogen-derived decoys that protect virulence factors. Trends Plant Sci. 22, 355-357. pubmed
92. Sueldo, D. J., and Van der Hoorn, R. A. L. (2017) Plant life needs cell death, but does plant cell death need Cys proteases? FEBS Lett. 284, 1577-1585. pubmed
91. Kovacs, J., Poor, P., Kaschani, F., Chandrasekar, B., Hong, T. N., Misas-Villamil, J. C., Xin, B. T., Kaiser, M., Overkleeft, H. S., Tari, I., and Van der Hoorn, R. A. L. (2017) Proteasome activity profiling uncovers alteration of catalytic beta-2 and beta-5 subunits of the stress-induced proteasome during salinity stress in tomato roots. Frontiers Plant Sci. 8, 107. pubmed
90. Misas, J. C., Van der Burgh, A., Grosse-Holz, F., Bach-Pages, M., Kaschani, F., Schilasky, S., Emon, A. E. K., Ruben, M., Kaiser, M., Overkleeft, H. S., and Van der Hoorn, R. A. L. (2017) Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections. Plant J. 90, 418-430. pubmed
89. Pruzinska, A., Shindo, T., Niessen, S., Kaschani, F., Toth, R., Millar, A. H., and Van der Hoorn, R. A. L. (2017) Major Cys protease activities are not essential for senescence in individually darkened Arabidopsis leaves. BMC Plant Biol. 17, 4. pubmed
88. Chandrasekar, B., Hong, T. N., and Van der Hoorn, R. A. L. (2017) Inhibitor discovery by convolution ABPP. Meth. Mol. Biol. 1491, 47-56. pubmed
2016
87. Shindo, T., Kaschani, F., Yang, F., Kovacs, J., Tian, F., Kourelis, J., Hong, T. N., Colby, T., Shabab, M., Chawla, R., Kumari, S., Ilyas, M., Hoerger, A., Alfano, J. R., and Van der Hoorn, R. A. L. (2016) Screen of non-annotated small secreted proteins of Pseudomonas syringae reveals a virulence factor that inhibits tomato immune proteases. PLoS Pathog. 12, e1005874 pubmed
86. Misas-Villamil, J. C., Van der Hoorn, R. A. L., and Doehlemann, G. (2016) Papain-like cysteine proteases as hubs in plant immunity. New Phytol. 212, 902-907. pubmed
85. Daneri-Castro, S. N., Chandrasekar, B., Grosse-Holz, F. M., Van der Hoorn, R. A. L., and Roberts, T. H. (2016) Activity-based protein profiling of hydrolytic enzymes induced by gibberellic acid in isolated aleurone layers of malting barley. FEBS Lett. 590, 2956-2962. pubmed
84. Paireder, M., Mehofer, U., Tholen, S., Porodko, A., Schahs, P., Biniossek, M. L., Van der Hoorn, R. A. L., Lenarcic, B., Novinec, M., Schilling, O., and Mach, L. (2016) The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity. Arch. Biochem. Biophys. 603, 110-107. pubmed
83. Kovacs, J., and Van der Hoorn, R. A. L. (2016) Twelve ways to confirm targets of activity-based probes in plants. Bioorg. Med. Chem. 24, 3304-3311. pubmed
++ Van der Hoorn, R. A. L. (2016) Exploring antagonistic interactions in the plant apoplast. Biology News (Oxford University) 5, 11. pdf
82. Kaschani, F., Wei, Q., Dingemans, J., Van der Hoorn, R. A. L., Cornelis, P., and Kaiser, M. (2016) Capture of endogenously biotinylated proteins from Pseudomonas auruginosa displays unexpected regulation of LiuD upon iron nutrition. Bioorg. Med. Chem. 24, 3330-3335. pubmed
81. Kourelis, J., Van der Hoorn, R. A. L., Sueldo, D. J. (2016) Decoy engineering: the next step in resistance breeding. Trends Plant Sci. 21, 371-373. pubmed
80. Stiti, N., Chandrasekar, B., Strubl, L., Mohammed, S., Bartels, D., and Van der Hoorn, R. A. L. (2016) Nicotinamide cofactors suppress active-site labeling of aldehyde dehydrogenases. ACS Chem. Biol. 11, 1578-1586. pubmed
79. Malik, S., and Van der Hoorn, R. A. L. (2016) Inspirational decoys: a new hunt for effector targets. New Phytologist 210, 371-373. pubmed
78. Poret, M., Chandrasekar, B., Van der Hoorn, R. A. L., and Avice, J. -B. (2016) Characterization of senescence-associated protease activities in the efficient protein remobilization during leaf senescence of winter oilseed rape. Plant Sci. 246, 139-153. pubmed
77. Morimoto, K., and Van der Hoorn, R. A. L. (2016) The increasing impact of activity-based protein profiling in plant science. Plant Cell Physiol. 57, 446-461 pubmed
76. Grosse-Holz, F., and Van der Hoorn, R. A. L. (2016) Juggling jobs: roles and mechanims of multifunctional protease inhibitors in plants. New Phytologist 57, 446-461 pubmed
75. Chandrasekar, B., and Van der Hoorn, R. A. L. (2016) Beta-galactosidases in Arabidopsis and tomato: a mini review. Biochem. Transact. 44, 150-158 pubmed PDF
2015
74. Hütten, M., Geukes, M., Misas-Villamil, J. C., van der Hoorn, R. A. L., Grundler, F. M., and Siddique, S. (2015) Activity profiling reveals changes in the diversity and activity of proteins in Arabidopsis roots in response to nematode infection. Plant Physiol Biochem. 97, 36-43. pubmed
73. Ilyas, M., Hörger, A. C., Bozkurt, T. O., Van den Burg, H. A., Kaschani, F., Kaiser, M., Belhaj, K., Smoker, M., Joosten, M. H. A. J., Kamoun, S., and Van der Hoorn, R. A. L. (2015) Functional divergence of two secreted immune proteases of tomato. Current Biol. 25, 2300-2306. pubmed
72. Lu, H., Chandrasekar, B., Oeljeklaus, J., Misas-Villamil, J. C., Wang, Z., Shindo, T., Bogyo, M., Kaiser, M., and Van der Hoorn, R. A. L. (2015) Subfamily-specific probes for Cys proteases display dynamic protease activities during seed germination. Plant Physiol. 168, 1462-1475. pubmed
71. Ting, H. M., Delatte, T. L., Kolkman, P., Misas-Villamil, J. C., Van der Hoorn, R. A. L., Bouwmeester, H. J., and Van der Krol, A. R. (2015) SNARE-RNAi results in higher terpene emission from ectopically expressed caryophyllene synthase in Nicotiana benthamiana. Mol. Plant 8, 454-466. pubmed
2014
++ Van der Hoorn, R. A. L. (2014) Determining the fate of proteins. International Innovation 141, 22-24. PDF website
70. Chandrasekar, B., Colby, T., Emon, A. E. K., Jiang, J., Hong, T. N., Villamor, J. G., Harzen, A., Overkleeft, H. S., and Van der Hoorn, R. A. L. (2014) Broad range glycosidase activity profiling. Mol. Cell. Proteomics. 13, 2787-2800. pubmed
69. Zhang, B., Tremousaygue, D., Denancé, N., Van Esse, H. P., Hörger, A. C., Dabos, P., Goffner, D., Thomma, B. P. H. J., Van der Hoorn, R. A. L., Tuominen, H. (2014) PIRIN2 stabilizes cysteine protease XCP2 and increases susceptibility to the vascular pathogen Ralstonia solanacearum in Arabidopsis. Plant J. 79, 1009-1019. pubmed
68. Sueldo, D., Ahmed, A., Misas-Villamil, J. C., Colby, T., Tameling, W., Joosten, M. H. A. J., and Van der Hoorn, R. A. L. (2014) Dynamic hydrolase activities precede hypersensitive tissue collapse in tomato seedlings. New Phytologist 203, 913-925. pubmed
67.Dong, S., Stam, R., Cano, L. M., Song, J., Sklenar, J., Yoshida, K., Bozkurt, T. O., Oliva, R., Liu, Z., Tian, M., Win, J., Banfield, M. J., Jones, A. M., Van der Hoorn, R. A. L., and Kamoun, S. (2014) Effector specialization in a lineage of the Irish potato famine pathogen. Science 343, 552-555. pubmed PDF Highlighted in Science, The Scientist, Science Daily, Smallholder, SeedDaily, BBSRC, PhysOrg, HispanicBusiness, Science Codex, PlantSci, RedOrbit, Vegetable Farmer, Agrotimes, Solar Daily, and Oxford.
66. Hong, T. N., and Van der Hoorn, R. A. L. (2014) DIGE-ABPP by click chemistry: pairwise comparison of serine hydrolase activities from the apoplast of infected plants. Meth. in Mol. Biol. 1127, 183-194. pubmed
2013
65. Ilyas, S., Ilyas, M., Van der Hoorn, R. A. L., and Mathur, S. (2013) Selective conjugation of proteins in mining the active proteome through click-functionalized magnetic nanoparticles. ACS Nano 7, 9655-9663. pubmed
64. Hörger, A. C., and Van der Hoorn, R. A. L. (2013) The structural basis of specific protease-inhibitor interactions at the plant-pathogen interface. Curr. Opin. Struct. Biol. 23, 843-850. pubmed
63. Zulet, A., Gil-Monreal, M., Villamor, J. G., Zabalza, A., Van der Hoorn, R. A. L., and Royuela, M. (2013) Proteolytic pathways induced by herbicides that inhibit amino acid biosynthesis. PLoS One 8, e73847. pubmed
62. Villamor, J. G., Kaschani, F., Colby, T., Oeljeklaus, J., Zhao, D., Kaiser, M., Patricelli, M. P., and Van der Hoorn, R. A. L. (2013) Profiling protein kinases and other ATP binding proteins in Arabidopsis using acyl-ATP probes. Mol. Cell. Proteomics 12, 2481-2496. pubmed
61. Misas-Villamil, J. C., Kolodziejek, I., Crabill, E., Kaschani, F., Niessen, S., Shindo, T., Kaiser, M., Alfano, J. R., and Van der Hoorn, R. A. L. (2013) Pseudomonas syringae pv. syringae uses proteasome inhibitor Syringolin A to colonize from wound infection sites. PLoS Pathogens. 9, e1003281. pubmed
60. Gu, C., Shannon, A., Colby, T., Wang, Z., Shabab, M., Kumari, S., Villamor, J. G., McLaughlin, C. J., Weerapana, E., Kaiser, M., Cravatt, B. F., and Van der Hoorn, R. A. L. (2013) Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutatione transferases. Chem. & Biol. 20, 541-548. pubmed PDF Highlighted by Dr. Verhelst in same issue!
59. Nguyen, H. M., Schippers, J. H., Goni-Ramos, O., Christoph, M. P., Dortay, H., Van der Hoorn, R. A. L., and Mueller-Roeber, B. (2013) An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana. Plant J. 74, 25-36. pubmed
58. Lu, H., Wang, Z., Shabab, M., Oeljeklaus, J., Verhelst, S. H., Kaschani, F., Kaiser, M., Bogyo, M., and Van der Hoorn, R. A. L. (2013) A substrate-inspired probe monitors translocation, activation and subcellular targetting of bacterial type III effector protease AvrPphB. Chem. & Biol. 20, 168-176. pubmed Highlighted by Dr. Blum in same issue!
57. Misas-Villamil, J. C., Toenges, G., Kolodziejek, I., Sadaghiani, A. M., Kaschani, F., Colby, T., Bogyo, M., and Van der Hoorn, R. A. L. (2013) Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection. Plant J. 73, 689-700. pubmed
++. Van der Hoorn, R. A. L. RD21 Peptidase. Book chapter in Handbook of proteolytic enzymes, 3rd edition. (N. Rawings & G. Salvesen, eds.), Elsevier 2013, 1892–1896. link
2012
56. Stolze*, S. C., Deu* E., Kaschani*, F., Li, N., Florea, B. J., Richau, K. H., Colby, T., Van der Hoorn, R. A. L., Overkleeft, H. S., Bogyo, M., and Kaiser, M. (2012) The antimalarial natural product Symplostatin 4 is a nanomolar inhibitor of the food vacuole Falcipains. Chem. & Biol. 19, 1546-1555. pubmed
55. Shannon, D., A., Gu, C., McLaughlin, C. J., Kaiser, M., Van der Hoorn*, R. A. L., and Weerapana*, E. (2012) Sulfonyl-fluoride analogs as activity-based probes for serine proteases. ChemBioChem, 13, 2327-2330. pubmed
54. Van der Linde, K., Mueller, A. N., Hemetsberger, C., Kaschani, F., Van der Hoorn, R. A. L., and Doehlemann, G. (2012) The maize cystatin CC9 interacts with apoplastic cysteine proteases. Plant Sign. Behav. 7, 1397-1401. pubmed
53. Hörger, A. C., Ilyas, M., Stephan, W., Tellier, A., Van der Hoorn*, R. A. L. and Rose*, L. E. (2012) Balancing selection at the tomato RCR3 guardee gene family maintains variation in strength of pathogen defense. PLoS Genetics 8, e1002813. pubmed PDF
52. Lozano-Torres, J. L., Wilbers, R. H. P., Gawronski, P., Boshoven, J. C., Finkers-Tomczak, A., Cordewener, J. H. G., America, A. H. P., Overmars, H. A., Van 't Klooster, J. W., Baranowski, L., Sobczak, M., Ilyas, M., Van der Hoorn, R. A. L., Schots, A., De Wit, P. J. G. M., Bakker, J., Goverse, A., and Smant, G. (2012) Dual disease resistance mediated by immune receptor Cf-2 in tomato require a common virulence target of a fungus and a nematode. Proc. Nat. Acad. Sci. USA 109, 10119-10124. pubmed
51. Richau, K., Kaschani, F., Verdoes, M., Pansuriya, T. C., Niessen, S., Stüber, K., Overkleeft, H. S., Bogyo, M., and Van der Hoorn, R. A. L. (2012) Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics. Plant Physiol. 158, 1583-1599. pubmed
50. Van der Linde, K., Hemetsberger, C., Kastner, C., Kaschani, F., Van der Hoorn, R. A. L., Kumlehn, J., and Doehlemann, G. (2012) A maize cystatin suppresses host immunity by inhibition of apoplastic cysteine proteases. Plant Cell 24, 1285-1300. pubmed
49. Kaschani, F., Clerc, J., Krahn, D., Ottmann, C., Bier, D., Ngoc Hong, T., Ottmann, C., Niessen, S., Colby, T., Van der Hoorn, R. A. L., and Kaiser, M. (2012) Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases. Angew. Chem. Int. Ed. 51, 5230-5233. pubmed
48. Gu, C., Shabab, M., Strasser, R., Wolters, P. J., Shindo, T., Niemer, M., Kaschani, F., Mach, L., and Van der Hoorn, R. A. L. (2012) Post-translational regulation and trafficking of the granulin-containing protease RD21 of Arabidopsis thaliana. PLoS One 7, e32422. pubmed PDF
47. Ottmann, C., Van der Hoorn, R. A. L., and Kaiser, M. (2012) The impact of plant-pathogen studies on medicinal drug discovery. Chem. Soc. Rev. 41, 3168-3178 pubmed
46. Kaschani, F., Gu, C., and Van der Hoorn, R. A. L. (2012) Activity-based protein profiling of infected plants. Meth. Mol. Biol. 835, 47-59. pubmed PDF
45. Shindo, T., Misas-Villamil, J. C., Hörger, A., Song, J., and Van der Hoorn, R. A. L. (2012) A role in immunity for Arabidopsis cysteine protease RD21, the ortholog of the tomato immune protease C14. PLoS One 7, e29317. pubmed
44. Kaschani, F., Nickel, S., Pandey, B., Cravatt, B.F., Kaiser, M., and Van der Hoorn, R. A. L. (2012) Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP. Bioorg. Med. Chem. 20, 597-600. pubmed PDF
43. Lenger, J., Kaschani, F., Lenz, T., Dalhoff, C., Villamor, J. G., Koster, H., Sewald, N., and Van der Hoorn, R. A. L. (2012) Labeling and enrichment of Arabidopsis thaliana matrix metalloproteases using an active-site directed, marimastat-based photoreactive probe. Bioorg. Med. Chem.20, 592-596. pubmed
42. Nickel, S., Kaschani, F., Colby, T., Van der Hoorn, R. A. L., and Kaiser, M. (2012) A para-nitrophenol phosphonate probe labels distinct serine hydrolases in Arabidopsis. Bioorg. Med. Chem. 20, 601-606. pubmed
++. Van der Hoorn, R. A. L., Gu, C., Kaschani, F., Misas-Villamil, J. C., Richau, K., Kolodziejek, I., Moquet, F., Malliart, C., Berthet, X., Goni-Ramos, O., Ellul, P. (2012) Seed trait prediction by activity-based protein profiling. WO Patent 2012100963
2011
41. Bozkurt, T., Schornack, S., Win, J., Shindo, T., Ilyas, M., Oliva, R., Cano, L. M., Jones, A. M. E., Huitema, E., Van der Hoorn, R. A. L., and Kamoun, S. (2011) Phytophthora infestans effector AVRblb2 prevents secretion of a plant immune protease at the haustorial interface. Proc. Natl. Acad. Sci USA. 108, 20832-20837. pubmed
40. Van der Hoorn, R. A. L., and Kaiser, M. (2012) Probes for activity-based profiling of plant proteases. Physiol. Plantarum 145, 18-27. pubmed
39. Van der Hoorn, R. A. L., Colby, T., Nickel, S., Richau, K., Schmidt, J., and Kaiser, M. (2011) Mining the active proteome of Arabidopsis thaliana. Frontiers Plant Physiol. 2, 89. pubmed
38. Kumari, S., and Van der Hoorn, R. A. L. (2011) A structural biology perspective on bioactive small molecules and their plant targets. Curr. Opin. Plant Biol. 14, 480-488. pubmed
37. Misas-Villamil*, J. C., Kolodziejek*, I., and Van der Hoorn, R. A. L. (2011) Pseudomonas syringae colonizes distant tissues in Nicotiana benthamiana through xylem vessels. Plant J. 67, 774-782. pubmed
36. Kaschani, F., and Van der Hoorn, R. A. L. (2011) A model of the C14-EPIC complex indicates hotspots for a protease-inhibitor arms race in the oomycete-potato interaction. Plant Signal. Behav. 6, 1-4. pubmed
35. Kolodziejek*, I., Misas-Villamil*, J. C., Kaschani, F., Clerc, J., Gu, C., Krahn, D., Niessen, S., Verdoes, M., Willems, L. I., Overkleeft, H. S., Kaiser, M. and Van der Hoorn, R. A. L. (2011) Proteasome activity imaging and profiling characterizes bacterial effector Syringolin A. Plant Physiol. 155, 477-489. pubmed
34. Richau, K. H., and Van der Hoorn, R. A. L. (2011) Studies on plant-pathogen interactions using activity-based proteomics. Curr. proteomics 7, 328-336. website
33. Lenz, H. D., Haller, E., Melzer, E., Kober, K., Wurster, K., Stahl, M., Bassham, D. C., Vierstra, R. D., Parker, J. E., Bautor, J., Molina, A., Escudero, V., Shindo, T., Van der Hoorn, R. A. L., Gust, A. A., and Nuernberger, T. (2011) Autophagy differentially controls plant basal immunity to biotrophic and necrotrophic pathogens. Plant J. 66, 818-830. pubmed
2010
32. Kaschani, F., Shabab, M., Bozkurt, T., Shindo, T., Schornack, S., Gu, C., Ilyas, M., Win, J., Kamoun, S., and Van der Hoorn, R. A. L. (2010) An effector-targeted protease contributes to defense against Phytophthora infestans and is under diversifying selection in natural hosts. Plant Physiol. 154, 1794-1804. pubmed
++. Van der Hoorn, R. A. L., Gu, C., Ilyas, M., Kolodziejek, I., Kumari, S., Misas-Villamil, J. C., Pruzinska, A., Richau, K. H., Shabab, M., Shindo, T., Wang, Z. and Kaschani, F. (2010) Mining the active proteome in plant-pathogen interactions. In: Biology of Plant-Microbe Interactions, Volume 7. H. Antound, T. Avis, L. Brisson, D. Prevost, and M. Trepanier, eds. International Society for Molecular Plant-Microbe Interactions, St. Paul, MN.
31. Kolodziejek, I., and Van der Hoorn, R. A. L. (2010) Mining the active plant proteome in plant science and biotechnology. Curr. Opin. Biotechn. 21, 225-233. pubmed
30. Gu, C., Kolodziejek, I., Misas-Villamil, J. C., Shindo, T., Colby, T., Verdoes, M., Richau, K. H., Schmidt, J., Overkleeft, H. S., and Van der Hoorn, R. A. L. (2010) Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defence-induced proteasome activities. Plant J. 62, 160-170. pubmed PDF
29. Toth, R., and Van der Hoorn, R. A. L. (2010) Emerging principles in plant chemical genetics. Trends in Plant Sci. 15, 81-88. pubmed
2009
28. Kaschani*, F., Gu*, C., Niessen, S., Hoover, H., Cravatt, B. F., and Van der Hoorn, R. A. L. (2009) Diversity of Serine hydrolase activities of non-challenged and Botrytis-infected Arabidopsis thaliana. Mol. Cell. Proteomics 8, 1082-1093 pubmed PDF
27. Song, J., Win, J., Tian, M., Schornack, S., Kaschani, F., Muhammad, I., Van der Hoorn, R. A. L., and Kamoun, S. (2009) Apoplastic effectors secreted by two unrelated eukaryotic plant pathogens target the tomato defense protease Rcr3. Proc. Natl. Acad. Sci. USA 106, 1654-1659. pubmed
26. Hogenhout, S. A., Van der Hoorn, R. A. L., Terauchi, R., and Kamoun, S. (2009) Emerging concepts in effector biology of plant-associated organisms. Mol. Plant-Microbe Interact. 22, 115-122.pubmed
25. Kaschani, F., Verhelst, S. H. L., Van Swieten, P. F., Verdoes, M., Wong, C. -S., Wang, Z., Kaiser, M., Overkleeft, H. S., Bogyo, M., and Van der Hoorn, R. A. L. (2009) Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click-chemistry'. Plant J.57, 373-385. pubmed PDF
++. Van der Hoorn, R. A. L. Activity-based protein profiling of Cys proteases. Book chapter in: Chemical Biology. Learning through case studies. (H. Waldmann, P. Janning, eds.) Wiley VCH, 2009, pp69-78.
2008
24. Van der Hoorn, R. A. L., and Kamoun, S. (2008) From guard to decoy: a new model for perception of plant pathogen effectors. Plant Cell 20, 2009-2017. pubmed
23. Wang*, Z., Gu*, C., Colby, T., Shindo, T., Balamurugan, R., Waldmann, H., Kaiser, M., and Van der Hoorn, R. A. L. (2008) Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nat. Chem. Biol. 4, 557-563. pubmed Highlighted by Carrico I., Nat. Chem. Biol. (2008) pressrelease (German)
22. Misas-Villamil, J. C., and Van der Hoorn, R. A. L. (2008) Enzyme-inhibitor interactions at the plant-pathogen interface. Curr. Opin. Plant Biol. 11, 380-388 pubmed
21. Shabab*, M., Shindo*, T., Gu, C., Kaschani, F., Pansuriya, T., Chintha, R., Harzen A., Colby, T., Kamoun, S., and Van der Hoorn, R. A. L. (2008) Fungal effector protein AVR2 targets diversifying defence-related Cys proteases of tomato. Plant Cell 20, 1169-1183. pubmed
20. Van der Hoorn, R. A. L. (2008) Plant proteases: from phenotypes to molecular mechanisms. Ann. Rev. Plant Biol. 59, 191-223. pubmed PDF
19. Shindo, T., and Van der Hoorn, R. A. L. (2008) Papain-like cysteine proteases: key players at molecular battlefields employed by both plants and their invaders. Mol. Plant Pathol. 9, 119-125. MPP
2007
18. Gilroy, E., Hein, I., Van der Hoorn, R. A. L., Boevink, P., Venter, E., McLellan, H., Kaffarnik, F., Hrubikova, K., Shaw, J., Holeva, M., Lopez, E., Hidalgo, O., Pritchard, L., Loake, G., Lacomme, C., and Birch, P. (2007) Involvement of cathepsin B in the plant disease resistance hypersensitive response. Plant J. 52, 1-13. pubmed
++. Kaschani, F., and Van der Hoorn, R. A. L. (2007) Anwendung von activity-based proteomics zur Analyse von Pflanzen-Pathogen Interaktionen. Max Planck Society Yearbook 2007, 625-629. link
17. Kaschani, F., and Van der Hoorn, R. A. L. (2007) Small molecule approaches in plants. Curr. Opin. Chem. Biol. 11, 88-98. pubmed
16. Tian, M., Win, J., Song, J., Van der Hoorn, R. A. L., Van der Knaap, E., and Kamoun, S. (2007) A Phytophthora infestans cystatin-like protein interacts with and inhibits a tomato papain-like apoplastic protease. Plant Physiol. 143, 364-277. pubmed
2005
15. Rooney*, H., Van ’t Klooster*, J., Van der Hoorn, R. A. L., Joosten, M. H. A. J., Jones, J. D. G., and De Wit, P. J. G. M. (2005) Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance. Science 308, 1783-1789. pubmed
Recommended in faculty 1000.
14. Van der Hoorn*, R. A. L., Wulff*, B., Rivas*, S., Durrant, M. C., Van der Ploeg, A., De Wit, P. J. G. M., and Jones, J. D. G. (2005) Structure-function analysis of Cf-9, a receptor-like protein with extracytoplasmic leucine-rich repeats. Plant Cell 17, 1000-1015. pubmed
2004
13. Van der Hoorn, R. A. L. and Jones, J. D. G. (2004) The plant proteolytic machinery and its role in defence. Curr. Opin. Plant Biol. 7, 400-407. pubmed
12. Van der Hoorn, R. A. L., Leeuwenburgh, M. A, Bogyo, M., Joosten, M. H. A. J., and Peck, S. C. (2004) Activity profiling of papain-like cysteine proteases in plants. Plant Physiol. 135, 1170-1178. pubmed Highlighted in faculty 1000.
2003
11. Van der Hoorn, R. A. L., Rivas, S., Wulff, B. B. H., Jones, J. D. G., and Joosten, M. H. A. J. (2003). Rapid migration in gel filtration of the Cf-4 and Cf-9 resistance proteins is an intrinsic property of Cf proteins and not because of their association with high-molecular-weight proteins. Plant J. 35, 305-315. pubmed
2002
10. Van der Hoorn, R. A. L., De Wit, P. J. G. M., and Joosten, M. H. A. J. (2002) Balancing selection favors guarding resistance proteins. Trends Plant Sci. 6, 67-71. pubmed
2001
9. Van der Hoorn, R. A. L., Roth, R., and De Wit, P. J. G. M. (2001) Identification of distinct specificity determinants in resistance protein Cf-4 allows construction of a Cf-9 mutant that confers recognition of avirulence protein AVR4. Plant Cell 13, 273-285. pubmed
8. Van der Hoorn, R. A. L., Van der Ploeg, A., De Wit, P. J. G. M., and Joosten, M. H. A. J. (2001) The C-terminal dilysine motif for targeting to the endoplasmic reticulum is not required for Cf-9 function. Mol. Plant-Microbe Interact. 14, 412-415. pubmed
7. Van der Hoorn*, R. A. L., Kruijt*. M., Roth, R., Brandwagt, B. F., Joosten, M. H. A. J., and De Wit, P. J. G. M. (2001) Intragenic recombination generated two distinct Cf genes that mediate AVR9 recognition in the natural population of Lycopersicon pimpinellifolium. Proc. Natl. Acad. Sci. USA 98, 10493-10498. pubmed
6. Joosten, M. H. A. J., Brandwagt, B. F., Van der Hoorn, R. A. L., De Jong, C. F., Van 't Klooster, J. W., De Kock, M. J. D., Kruijt, M., Luderer, R., Takken, F. L. W., Westerink, N. and De Wit, P. J. G. M. (2001) The role of secreted proteins of the pathogenic fungus Cladosporium fulvum in (a) virulence on its host, tomato. Phytopathology 91, S161.
5. De Wit, P. J. G. M., Brandwagt, B. F., Van den Burg, H. A., Cai, X., Van der Hoorn, R. A. L., De Jong, C. F., Van't Klooster, J., De Kock, M. J. D., Kruijt, M., Lindhout, W. H., Luderer, R., Takken, F. L. W., Westerink, N., Vervoort, J. J. M., Joosten, M. H. A. J. (2001) The molecular basis of co-evolution between Cladosporium fulvum and tomato. Anton. Leeuw. Int. J. G. 81, 409-412. pubmed
2000
4. Van der Hoorn, R. A. L., Laurent, F., Roth, R., and De Wit, P. J. G. M. (2000) Agroinfiltration is a versatile tool that facilitates comparative analysis of Avr9/Cf-9-induced and Avr4/Cf-4-induced necrosis. Mol. Plant-Microbe Interact. 13,439-446. pubmed
3. Luderer, R., Rivas, S., Nürnberger, T., Mattei, B., Van den Hooven, H. W., Van der Hoorn, R. A. L., Romeis, T., Wehrfritz, J. M., Blume, B., Nennstiel, D., Zuidema, D., Vervoort, J., De Lorenzo, G., Jones, J. D. G., De Wit, P. J. G. M., and Joosten, M. H. A. J. (2000) No evidence for binding between resistance gene product Cf-9 of tomato and avirulence gene product AVR9 of Cladosporium fulvum. Mol. Plant-Microbe Interact. 14, 867-876. pubmed
2. Stam, M., De Bruin, R., Van Blokland, R., Van der Hoorn, R. A. L., Mol, J. N. M., and Kooter, J. M. (2000) Distinct features of post-transcriptional gene silencing by antisense transgenes in single copy and inverted T-DNA repeat loci. Plant J. 21, 27-42. pubmed
++. Joosten, M. H. A. J., Cai, X. Z., Van der Hoorn, R. A. L., De Jong, C. F., De Kock, M., Lauge, R., Luderer, R., Roth, R., Takken, F., Vossen, P., Weide, R., Westerink, N., De Wit, P. J. G. M. (2000) Fungal (A)virulence and host resistance in the Cladosporium fulvum-tomato interaction. Book chapter in: Biology of Plant-Microbe Interactions. Vol.2, APS-PRESS 2000, 29-34.
1997
1. Stam, M., De Bruin, R., Kenter, S., Van der Hoorn, R. A. L., Van Blokland, R., Mol, J. N. M., and Kooter, J. M. (1997) Post-transcriptional silencing of chalcone synthase in Petunia by inverted transgene repeats. Plant J. 12, 63-82.
*, equal contibutions; underlined, teammember during contribution
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